Accentuated aging associated with HIV in a Mediterranean setting occurs mainly in persons aged>70 years: a comparative cohort study (Over50 cohort). Issue 2 (1st February 2022)

• Record Type: Journal Article
• Authors: Negredo, Eugenia; Loste, Cora; Puig, Jordi; Echeverría, Patricia; Fumaz, Carmina R.; Muñoz-Moreno, Jose A.; Lemos, Begoña; Martínez, Ana; Tamayo, Fauri; Saiz, Margarita; Estany, Carla; Matarrodona, Marc; Bonjoch, Anna; Blanco, Nerea; Satorra, Pau; Clotet, Bonaventura
• Is Part Of: AIDS care. Volume 34:Issue 2(2022)
• Page Start: 155
• Page End: 162
• Publication Date: 2022-02-01
• Subjects: Aging -- HIV infection -- comorbidities -- geriatric syndromes -- psychosocial aspects -- multidisciplinary assessment; AIDS (Disease) -- Social aspects -- Periodicals; AIDS (Disease) -- Psychological aspects -- Periodicals; AIDS (Disease) -- Patients -- Care -- Periodicals; Acquired Immunodeficiency Syndrome; 362.1969792
• DOI: 10.1080/09540121.2021.1998314
• Languages: English
• ISSNs: 0954-0121

Abstract

ABSTRACT: In an ongoing Mediterranean cohort, we compared age-related conditions between 208 HIV-infected persons and 104 matched controls. ≥3 comorbidities were found in 31.0% of HIV-infected patients and 8.7% of controls. Conditions significantly more frequent among the HIV-infected population were: lipid abnormalities, cancer, osteopenia/osteoporosis, liver disease, sexual dysfunction, hearing deficit, sleep disorders, falls, cognitive complaints, being single, living alone, and being elderly at risk. HIV-infected patients aged >70 years had a significantly higher number of cardiovascular risk factors (CVRF) and comorbidities than controls. HIV-infected persons who had never smoked had a higher prevalence of CVRFs, ≥3 comorbidities, liver disease, cancer, and cognitive complaints compared to controls. Factors associated with frailty were being a man who has sex with men, ≥3 CVRFs, nadir CD470 years. The multidisciplinary assessment also revealed concerning findings in social, cognitive, and functional variables among HIV-infected individuals, with a higher prevalence of elderly at risk than among controls.