E0167 The relationship study between T663A polymorphism of αENaC gene with essential hypertension and serum electrolytes in Xinjiang Kazakhs. (17th November 2010)

• Record Type: Journal Article
• Authors: Nanfang, Li; Hong, Xu; Xiaoguang, Yao; Zhitao, Yan
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A54
• Page End: A54
• Publication Date: 2010-11-17
• Subjects: Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.167
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Introduction: To study the relationship between the T663A polymorphism in αENaC gene with essential hypertension (EH) and serum electrolytes of Xinjiang Kazakhs. Methods: 516 Xinjiang Kazakhs aged elder than 30 years were recruited in this population based on case-control study from the patural area of Xinjiang, and were divided into hypertensives (EH group) and normotensives (NT group). The gene polymorphism of T663A by PCR-RFLP and the serum electrolytes were examined. Results: The frequencies of AA, AG, GG genotypes were 15.7%, 50.2%, 34.1% and the frequencies of alleles A, G were 40.8%, 59.2%, respectively. The frequencies of AA, AG, GG were 16.3%, 49.1%, 34.6% in EH group and 15.1%, 51.4%, 33.5% in NT group, respectively. The distribution of genotypic and allelic frequencies were not different between EH group and NT group (p=0.85; p=1.0). No significant difference in levels of blood pressure and K +, Na + /K + between subjects among genotypes. The T663A polymorphism were excluded as independent variables controlling age and BMI. But the serum Na + of the subjects with AA genotype was higher than those subjects with AG and GG genotypes (p=0.032). Conclusions: T663A polymorphism might not be associated with EH but the AA genotype of T663A polymorphisms might be associated with the higher level of the serum Na + of Xinjiang Kazakhs.