Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review. (31st December 2022)

• Record Type: Journal Article
• Authors: de Souza Nascimento, Amanda Maria; de Oliveira Segundo, Victor Hugo; Felipe Camelo Aguiar, Ana Júlia; Piuvezam, Grasiela; Souza Passos, Thaís; Florentino da Silva Chaves Damasceno, Karla Suzanne Florentino da Silva; de Araújo Morais, Ana Heloneida
• Is Part Of: Journal of enzyme inhibition and medicinal chemistry. Volume 37:Number 1(2022)
• Page Start: 749
• Page End: 759
• Publication Date: 2022-12-31
• Subjects: Antimicrobial peptides -- bioactive proteins -- infectious diseases -- bacteria; Enzyme inhibitors -- Periodicals; Enzyme Inhibitors -- periodicals; Biochemistry -- periodicals; 572.7
• DOI: 10.1080/14756366.2022.2039918
• Languages: English
• ISSNs: 1475-6366

Abstract

Abstract: This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibacterial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demonstrated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous proteases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health.