Bio-engineered nano-vesicles for IR820 delivery: a therapy platform for cancer by surgery and photothermal therapy. Issue 7 (4th February 2022)

• Record Type: Journal Article
• Authors: Zhang, Xiaojie; Zhou, Changsheng; Wu, Fanghua; Gao, Chang; Liu, Qianqian; Lv, Peng; Li, Ming; Huang, Liyong; Wu, Ting; Li, Wengang
• Is Part Of: Nanoscale. Volume 14:Issue 7(2022)
• Page Start: 2780
• Page End: 2792
• Publication Date: 2022-02-04
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d1nr05601h
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : Schematic of G-Nvs@IR820 in the FL/PA imaging guided IGS/PTT therapy for HCC. Firstly, the synthesis of G-Nvs@IR820, and secondly, G-Nvs@IR820 were selectively bound to the Axl-overexpressing HCC tumor model, leading to specific FL/PA diagnosis and guided IGS/PTT. Abstract : Long-term unsolved health problems from pre-/intra-/postoperative complications and thermal ablation complications pose threats to liver-cancer patients. To reduce the threats, we propose a multimodal-imaging guided surgical navigation system and photothermal therapy strategy to improve specific labeling, real-time monitoring and effective treatment of hepatocellular carcinoma. Using a bioengineering approach, G-Nvs@IR820, a kind of human-cell-membrane nano-vesicle, was generated with growth arrest-specific 6 (Gas6) expressed on the membrane and with near-infrared absorbing dye (IR820) loaded into it, which is proven to be an effective nanoparticle-drug-delivery system for Axl-overexpressing hepatocellular carcinoma. G-Nvs@IR820 shows excellent features in vitro and in vivo . As Gas6 binds to Axl specifically, G-Nvs@IR820 has good targeting ability to the tumor site and also has a good ability to guide the further accurate obliteration of carcinoma from adjacent normal tissue in surgery with its highly resolved fluorescence/photoacoustic/surgical-navigation signals. Moreover, the G-Nvs@IR820 represented a new perspective for photothermal therapy. Briefly, Nvs@IR820 was synthesized at a gram scale with high affinity, specificity, and safety. It has promising potential in clinical application for IGS and PTT in Axl-overexpressing hepatoma carcinoma.