Dienylation of N-benzoylhydrazones with CF3-substituted homoallenylboronates in water. Issue 7 (28th January 2022)

• Record Type: Journal Article
• Authors: Ma, Wei-Wei; Yang, Chao; Xie, Qiang; Xu, Yun-He
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 7(2022)
• Page Start: 1386
• Page End: 1390
• Publication Date: 2022-01-28
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02335g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A convenient method for the dienylation of N -benzoylhydrazones in water has been developed. Abstract : A convenient method for the dienylation of N -benzoylhydrazones in water has been developed. This protocol expanded the synthetic application of functionalized homoallenylboronates to provide the useful 2-aminomethyl-1, 3-diene derivatives with high efficiency (up to 99% yield) and stereoselectivity without using any catalyst, additive or inert atmosphere. Furthermore, the transformation of a 2-aminomethyl-1, 3-diene derivative to synthesize a functionalized pyrrolidine derivative was also explored.