Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model. Issue 15 (2nd February 2022)

• Record Type: Journal Article
• Authors: Utomo, Rohmad Yudi; Sugie, Atsushi; Okada, Satoshi; Miura, Kazuki; Nakamura, Hiroyuki
• Is Part Of: Chemical communications. Volume 58:Issue 15(2022)
• Page Start: 2576
• Page End: 2579
• Publication Date: 2022-02-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d1cc07000b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Curcumin derivatives B and N developed as disaggregation agents of amyloid β (Aβ) fibrils significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease. Abstract : Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.