E0335 Role of QT interval dynamicity in predicting sudden death in patients with idiopathic dilated cardiomyopathy. (17th November 2010)

• Record Type: Journal Article
• Authors: Bao, Mingwei; Tan, Tuantuan; Yu, Shengbo; Chen, Kui; Huang, Congxin
• Is Part Of: Heart. Volume 96(2010)Supplement 3
• Page Start: A104
• Page End: A105
• Publication Date: 2010-11-17
• Subjects: QT Interval -- idiopathic dilated cardiomyopathy -- sudden death -- risk predicting; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.2010.208967.335
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : Objective: To investigate the role of QT interval dynamicity in predicting sudden death in patients with idiopathic dilated cardiomyopathy (DCM). Methods: 55 patients with DCM (DCM group) and 27 health people (Control group, Con) were enrolled according to certain criteria. Investigations included history collection, clinical examination, echocardiography, ECG and 24 h ambulatory ECG. Following indexes were determined, left ventricle end diastolic dimension (LVEDD), left ventricle ejection fraction (LVEF), QT dispersion (QTd), SDNN, the slope of QT/RR plots of the linear regression, ventricular premature beats (VPB) and non-sustained ventricular tachycardia (NSVT). Patients with DCM were followed-up until all cause death. Results: Comparing with Con group, the LVEDD, QTd, VPB/24 h, NSVT/24 h, QTe/RR slope and QTp/RR slope were higher in DCM group, while LVEF and SDNN were lower in DCM group (p<0.05). The LVEDD, LVEF, QTd, SDNN, QTe/RR slope and QTp/RR slope were significant different among DCM sudden death group, DCM non sudden death group and Con group (p<0.05). Comparing between DCM sudden death and non sudden death group, LVEF, SDNN, QTp/RR slope and QTp/RR slope shown significant difference (p<0.05). Comparing between DCM with NSVT and without NSVT group, LVEF, QTd, VPB/24 h, QTp/RR slope and QTp/RR slope shown significant difference (p<0.05). The sudden death rate of DCM patients with QTe/RR slope≥0.210 was higher than those <0.210 (54.5% vs 21.1%, p<0.05). Sudden death rate of QTp/RR slope≥0.190 was higher than those <0.190 (52.2% vs 21.9%, p<0.05). The sudden death rate of DCM patients with both LVEF 35% and NSVT+ was 62.5%. Combining QTe/RR≥0.210 with NSVT+ or LVEF 35%, the sudden death rates were 62.5% or 66.7%. Combining QTp/RR≥0.190 with NSVT+ or LVEF 35%, the sudden death rates were 66.7% or 61.5%. Combining QTe/RR≥0.210 or QTp/RR≥0.190 with NVST+ and LVEF 35%, the sudden death rates were 77.8% or 70.0%. Conclusions: QT/RR slope of DCM sudden death group was higher than DCM non sudden death and Con group significantly. QT/RR slope show high predicting value for sudden death in DCM patients independently or combined with NSVT or LVEF.