Noncoding RNA in age-related cardiovascular diseases. (June 2015)

• Record Type: Journal Article
• Authors: Greco, Simona; Gorospe, Myriam; Martelli, Fabio
• Is Part Of: Journal of molecular and cellular cardiology. Volume 83(2015:Jun.)
• Page Start: 142
• Page End: 155
• Publication Date: 2015-06
• Subjects: MicroRNA -- Long noncoding RNA -- Aging -- Cardiovascular disease; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2015.01.011
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Eukaryotic gene expression is tightly regulated transcriptionally and post-transcriptionally by a host of noncoding (nc)RNAs. The best-studied class of short ncRNAs, microRNAs, mainly repress gene expression post-transcriptionally. Long noncoding (lnc)RNAs, which comprise RNAs differing widely in length and function, can regulate gene transcription as well as post-transcriptional mRNA fate. Collectively, ncRNAs affect a broad range of age-related physiologic deteriorations and pathologies, including reduced cardiovascular vigor and age-associated cardiovascular disease. This review presents an update of our understanding of regulatory ncRNAs contributing to cardiovascular health and disease as a function of advancing age. We will discuss (1) regulatory ncRNAs that control aging-associated cardiovascular homeostasis and disease, (2) the concepts, approaches, and methodologies needed to study regulatory ncRNAs in cardiovascular aging and (3) the challenges and opportunities that age-associated regulatory ncRNAs present in cardiovascular physiology and pathology. This article is part of a Special Issue entitled "CV Aging". Highlights: Regulatory ncRNAs that control aging-associated cardiovascular homeostasis and disease The concepts, approaches, and methodologies needed to study regulatory RNAs in cardiovascular aging The challenges and opportunities that age-associated regulatory ncRNAs present in cardiovascular physiology and pathology