The role of autophagic degradation in the heart. (January 2015)

• Record Type: Journal Article
• Authors: Nishida, Kazuhiko; Taneike, Manabu; Otsu, Kinya
• Is Part Of: Journal of molecular and cellular cardiology. Volume 78(2015:Jan.)
• Page Start: 73
• Page End: 79
• Publication Date: 2015-01
• Subjects: αMHC-Cre+ transgenic mice expressing Cre recombinase under the control of α-myosin heavy chain promoter -- Ambra1 activating molecule in Beclin 1-regulated autophagy -- AMPK AMP-activated protein kinase -- Atg autophagy-related -- Bcl B-cell lymphoma -- Bnip3 Bcl-2/E1B 19 kDa-interacting protein 3-like protein -- DFCP1 double FYVE-containing protein 1 -- ER endoplasmic reticulum -- FoxO forkhead box class O -- GABARAP γ-aminobutyric acid receptor-associated protein -- HDAC histone deacetylase -- LC3 microtubule-associated protein 1 light chain 3 -- LAMP lysosome-associated membrane protein -- LVAD left ventricular assist device support -- mtDNA mitochondrial DNA -- MLC2v-Cre+ knock-in mice expressing Cre recombinase under the control of myosin light chain 2v promoter -- mTOR mammalian target of rapamycin -- Nix Nip3-like protein X -- PE phosphatidylethanolamine -- PINK1 PTEN-induced putative kinase protein 1 -- PI3K class III phosphoinositide 3-kinase -- PI3P phosphoinositide 3-phosphate -- p62/SQSTM1 sequestosome 1 -- ROS reactive oxygen species -- SNARE soluble N-ethylmaleimide-sensitive factor attachment protein receptor -- STX17 SNARE protein syntaxin 17 -- TAC thoracic transverse aortic constriction -- TF transcription factor -- TLR toll-like receptor -- ULK Unc-51-like kinase -- Vps vacuolar protein sorting; Autophagy -- Mitophagy -- Mitochondria -- Cardioprotection -- Inflammation -- Reverse remodeling; Cardiology -- Periodicals; Heart Diseases -- Periodicals; Molecular Biology -- Periodicals; Cardiologie -- Périodiques; Cardiology; Electronic journals; Periodicals; 616.12
• DOI: 10.1016/j.yjmcc.2014.09.029
• Languages: English
• ISSNs: 0022-2828

Abstract

Abstract: Autophagy has evolved as a conserved process for bulk degradation and recycling of cytoplasmic components, such as long-lived proteins and organelles. Macroautophagy is the most prevalent form and thus referred to as autophagy. Autophagy is initially considered to be a non-selective process as an adaptive response to nutrient starvation. However, damaged mitochondria are selectively removed by autophagy, called mitophagy. Autophagy plays essential roles in starvation, cardiac remodeling, reverse remodeling, aging and inflammation to maintain cellular homeostasis in the heart. This review discusses some recent advances in understanding the basic molecular mechanisms underlying autophagosome and autolysosome formation and mitophagy and the roles of autophagy in cardiomyopathy. This article is part of a Special Issue entitled "Mitochondria: From Basic Mitochondrial Biology to Cardiovascular Disease". Highlights: Autophagy is important for the quality control of proteins and organelles. There are two kinds of autophagy, non-selective and selective autophagy. Autophagy is essential to maintain cellular homeostasis in the heart. Autophagy is a cardioprotective mechanism against external stress.