Regioselective synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds via transition metal-free C–C and C–N bond formation. Issue 7 (2nd February 2022)

• Record Type: Journal Article
• Authors: Ge, Danhua; Sun, Li-Wen; Yu, Zi-Lun; Luo, Xin-Long; Xu, Pei; Shen, Zhi-Liang
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 7(2022)
• Page Start: 1493
• Page End: 1499
• Publication Date: 2022-02-02
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d1ob02443d
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A simple and practical Cs2 CO3 -promoted method for the synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds has been developed. Abstract : Few methods are known for the synthesis of nitroindole derivatives. A simple and practical Cs2 CO3 -promoted method for the synthesis of 6-nitroindole derivatives from enaminones and nitroaromatic compounds has been developed. Two new C–C and C–N bonds were formed in a highly regioselective manner under transition metal-free conditions.