Oxytocin system gene methylation is associated with empathic responses towards children. (March 2022)

• Record Type: Journal Article
• Authors: Spencer, Hannah; Parianen Lesemann, Franca H.; Kraaijenvanger, Eline J.; Overbeek, Geertjan; Montoya, Estrella R.; Branje, Susan; Boks, Marco P.M.; Bos, Peter A.
• Is Part Of: Psychoneuroendocrinology. Volume 137(2022)
• Publication Date: 2022-03
• Subjects: Empathy -- Oxytocin -- Facial EMG -- DNA methylation; Psychoneuroendocrinology -- Periodicals; Endocrinology -- Periodicals; Neurology -- Periodicals; Psychiatry -- Periodicals; Neuropsychoendocrinologie -- Périodiques; 616.8
• DOI: 10.1016/j.psyneuen.2021.105629
• Languages: English
• ISSNs: 0306-4530

Abstract

Abstract: Empathy is an essential component of sensitive caregiving behavior, which in turn is an important predictor of children's healthy social-emotional development. The oxytocin (OXT) system plays a key role in promoting sensitive parenting and empathy. In this study, we investigated how OXT system gene methylation was associated with empathic processes in nulliparous women ( M age = 23.60, SD =0.44)—measuring both physiological facial muscle responses and ratings of compassion and positive affect to affective images depicting children. Linear mixed effects analyses demonstrated that lower methylation levels in the OXT and OXTR genes were related to enhanced empathic responses. The effect of OXT system gene methylation on empathic processes was partly qualified by an interaction with individual variations in women's care motivation. Our findings provide experimental evidence for an association between the methylation of OXT system genes and empathy. Highlights: OXT and OXTR gene methylation relate to empathic responses towards children. Care motivation influences effects of OXT/OXTR methylation on empathic processes. Findings further elucidate how the oxytocin system may influence social behavior.