Different Contribution of the Monkey Prefrontal and Premotor Dorsal Cortex in Decision Making During a Transitive Inference Task. (1st March 2022)

• Record Type: Journal Article
• Authors: Ramawat, S.; Mione, V.; Di Bello, F.; Bardella, G.; Genovesio, A.; Pani, P.; Ferraina, S.; Brunamonti, E.
• Is Part Of: Neuroscience. Volume 485(2022)
• Page Start: 147
• Page End: 162
• Publication Date: 2022-03-01
• Subjects: auROC Area under Receiver Operating Characteristics -- DLPFC Dorsolateral Prefrontal Cortex -- Dn Distance from Equality Line -- PMd Dorsal Premotor Cortex -- ROC Receiver Operating Characteristics -- RT Reaction Time -- SD Standard Deviation -- SDist Symbolic Distance -- SEM Standard Error of Mean -- TI Transitive Inference; transitive inference task -- prefrontal cortex -- premotor cortex -- monkey -- decision-making; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2022.01.013
• Languages: English
• ISSNs: 0306-4522

Abstract

Graphical abstract: Highlights: Monkeys were trained to perform a transitive inference task. Performance was modulated by the degree of difficulty in comparing the pairs of items. Lower degrees of difficulty favored target location encoding in DLPFC and PMd. Encoding of target location occurred earlier in DLPFC than in PMd. Abstract: Several studies have reported similar neural modulations between brain areas of the frontal cortex, such as the dorsolateral prefrontal (DLPFC) and the premotor dorsal (PMd) cortex, in tasks requiring encoding of the abstract rules for selecting the proper action. Here we compared the neuronal modulation of the DLPFC and PMd of monkeys trained to choose the higher rank from a pair of abstract images (target item), selected from an arbitrarily rank-ordered set (A > B > C > D > E > F) in the context of a transitive inference task. Once acquired by trial-and-error, the ordinal relationship between pairs of adjacent images (i.e., A > B; B > C; C > D; D > E; E > F), monkeys were tested in indicating the ordinal relation between items of the list not paired during learning. During these decisions, we observed that the choice accuracy increased and the reaction time decreased as the rank difference between the compared items enhanced. This result is in line with the hypothesis that after learning, the monkeys built an abstract mental representation of the ranked items, where rank comparisons correspond to the items' position comparison on this representation. In both brain areas, we observed higher neuronal activity when the target item appeared in a specific location on the screen with respect to the opposite position and that this difference was particularly enhanced at lower degrees of difficulty. By comparing the time evolution of the activity of the two areas, we observed that the neural encoding of target item spatial position occurred earlier in the DLPFC than in the PMd.