Novel missense SETD1A variants in Japanese patients with schizophrenia: Resequencing and association analysis. (April 2022)

• Record Type: Journal Article
• Authors: Morikawa, Ryo; Watanabe, Yuichiro; Igeta, Hirofumi; Arta, Reza K.; Ikeda, Masashi; Okazaki, Satoshi; Hoya, Satoshi; Saito, Takeo; Otsuka, Ikuo; Egawa, Jun; Tanifuji, Takaki; Iwata, Nakao; Someya, Toshiyuki
• Is Part Of: Psychiatry research. Volume 310(2022)
• Publication Date: 2022-04
• Subjects: Developmental delay -- Genotyping -- Rare variant -- Schizophrenia -- SETD1A; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2022.114481
• Languages: English
• ISSNs: 0165-1781

Abstract

Highlights: We identified novel missense SETD1A variants exclusively in schizophrenia patients. A schizophrenia patient with a p.Glu857Gln variant had developmental delays. Novel missense SETD1A variants were not significantly associated with schizophrenia. Abstract: SETD1A has been identified as a substantial risk gene for schizophrenia. To further investigate the role of SETD1A in the genetic etiology of schizophrenia in the Japanese population, we performed resequencing and association analyses. First, we resequenced the SETD1A coding regions of 974 patients with schizophrenia. Then, we genotyped variants, prioritized via resequencing, in 2, 027 patients with schizophrenia and 2, 664 controls. Next, we examined the association between SETD1A and schizophrenia in 3, 001 patients with schizophrenia and 2, 664 controls. Finally, we performed a retrospective chart review of patients with prioritized SETD1A variants. We identified two novel missense variants (p.Ser575Pro and p.Glu857Gln) via resequencing. We did not detect these variants in 4, 691 individuals via genotyping. These variants were not significantly associated with schizophrenia in the association analysis. Additionally, we found that a schizophrenia patient with the p.Glu857Gln variant had developmental delays. In conclusion, novel SETD1A missense variants were exclusively identified in Japanese patients with schizophrenia. However, our study does not provide evidence for the contribution of these variants to the genetic etiology of schizophrenia in the Japanese population.