Thrombolysis: Observations and numerical models. (February 2022)

• Record Type: Journal Article
• Authors: Petkantchin, Remy; Padmos, Raymond; Boudjeltia, Karim Zouaoui; Raynaud, Franck; Chopard, Bastien
• Is Part Of: Journal of biomechanics. Volume 132(2022)
• Publication Date: 2022-02
• Subjects: Ischemic Stroke -- Thrombolysis -- Numerical modeling; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2021.110902
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: This perspective paper considers thrombolysis in the context of ischemic strokes, intending to build eventually a numerical model capable of simulating the thrombolytic treatment and predicting patient outcomes. Numerical modeling is a scientific methodology based on an abstraction of a system but requires understanding their spatio-temporal interactions. However, although important, the current knowledge on thrombolysis is fragmented in contributions from which it is difficult to obtain a complete picture of the process, especially in a clinically relevant setup. This paper discusses, from a general point of view, how to develop a numerical model to describe the evolution of a patient clot under the action of a thrombolytic drug. We will present critical, yet fundamental, open questions that have emerged during this elaboration and discuss original experimental observations that challenge some of our current knowledge of thrombolysis.