Rab GTPases in Parkinson's disease: a primer. Issue 7 (22nd December 2021)

• Record Type: Journal Article
• Authors: Lara Ordóñez, Antonio Jesús; Fasiczka, Rachel; Naaldijk, Yahaira; Hilfiker, Sabine
• Editors: Halliday, Glenda; Dzamko, Nicolas
• Is Part Of: Essays in biochemistry. Volume 65:Issue 7(2021)
• Page Start: 961
• Page End: 974
• Publication Date: 2021-12-22
• Subjects: leucine rich repeat kinase -- membrane trafficking -- Parkinson´s disease -- protein phosphorylation -- Rab GTPase; Biochemistry -- Periodicals; 572
• DOI: 10.1042/EBC20210016
• Languages: English
• ISSNs: 0071-1365

Abstract

Abstract: Parkinson's disease is a prominent and debilitating movement disorder characterized by the death of vulnerable neurons which share a set of structural and physiological properties. Over the recent years, increasing evidence indicates that Rab GTPases can directly as well as indirectly contribute to the cellular alterations leading to PD. Rab GTPases are master regulators of intracellular membrane trafficking events, and alterations in certain membrane trafficking steps can be particularly disruptive to vulnerable neurons. Here, we describe current knowledge on the direct links between altered Rab protein function and PD pathomechanisms.