Adherence to the dietary approaches to stop hypertension diet and non‐alcoholic fatty liver disease. (17th January 2022)

• Record Type: Journal Article
• Authors: Sun, Yuanyuan; Chen, Shuohua; Zhao, Xinyu; Wang, Yanhong; Lan, Yanqi; Jiang, Xiaozhong; Gao, Xiang; Wu, Shouling; Wang, Li
• Is Part Of: Liver international. Volume 42:Number 4(2022)
• Page Start: 809
• Page End: 819
• Publication Date: 2022-01-17
• Subjects: Chinese -- dietary approaches to stop hypertension -- non‐alcoholic fatty liver disease; Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.15156
• Languages: English
• ISSNs: 1478-3223

Abstract

Abstract: Background and Aims: The evidence of the relationship between dietary approaches to stop hypertension (DASH) and non‐alcoholic fatty liver disease (NAFLD) is limited. Thus, we conducted a cohort‐based case‐control study to examine whether adherence to the DASH diet was associated with lower NAFLD risk in China. Methods: We included 11 888 participants (2529 incident NAFLD and 9359 non‐NAFLD) from the Kailuan cohort with no history of hepatitis B/C infection and alcohol drinking. DASH score was calculated based on the energy‐adjusted consumption of vegetables, fruits, dairy, beans, grains, meats, fat, sodium and beverage, collected by a validated food frequency questionnaire. We used Logistic regression analysis to determine the NAFLD's risk according to the DASH score. Results: Higher DASH score was associated with lower risk of NAFLD. Compared with the lowest quintile of DASH score, the highest DASH quintile had a lower risk of occurring NAFLD, with odds ratio (OR) of 0.82 (95% confidence interval [CI]: 0.70‐0.96) in the multivariate model. Stratified analysis showed that the inverse association was only observed in women (OR = 0.67, 95% CI: 0.48‐0.94), and participants with overweight/obesity (OR = 0.79, 95% CI: 0.66‐0.94), fasting blood glucose <6.1 mmol/L (OR = 0.80, 95%: 0.67‐0.96), low density lipoprotein ≥3.4 mmol/L (OR = 0.71, 95% CI: 0.53‐0.96), high density lipoprotein ≥1.0 mmol/L (OR = 0.81, 95% CI: 0.69‐0.96), ALT < 40 U/L (OR = 0.79, 95% CI:0.67‐0.93) and C‐reactive protein ≥2.0 mg/L (OR = 0.56, 95% CI: 0.40‐0.78). Conclusions: Adherence to the DASH diet was inversely associated with a lower risk of NAFLD in the Chinese population. DASH diet should be highly recommended, especially for women and people with overweight/obesity and a high CRP level.