Cationic copolymer Sweetsop-shape nanospheres conjugating SalPhen-Zinc complex for excellent antimicrobial. (5th March 2022)

• Record Type: Journal Article
• Authors: Li, Xuemei; Zhu, Xinhua; Zhang, Yaping; Cao, Peng; Wang, Rongmin; He, Yufeng
• Is Part Of: European polymer journal. Volume 166(2022)
• Publication Date: 2022-03-05
• Subjects: Polymer antibacterial materials -- Antibacterial nanospheres -- Double active center -- SalPhen zinc complex -- Antimicrobic activity; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; Polymerization; Polymers; Periodicals; Electronic journals; 547.705
• DOI: 10.1016/j.eurpolymj.2022.111034
• Languages: English
• ISSNs: 0014-3057

Abstract

Graphical abstract: Highlights: An antibacterial Schiff-base Zn complex was conjugated into cationic copolymer nanospheres, which afforded SalPZn@PSNs. Double antibacterial active centers were successfully constructed in SalPZn@PSNs. The antibacterial activity of SalPZn@PSNs was effectively enhanced. It also showed significant activity against apple tree rot fungus. SalPZn@PSNs was candidate as antimicrobials applied in agricultural field. Abstract: The occurrence of pathogenic infections, including fungi and bacteria, are easy to cause extremely serious consequences, such as fatal diseases, crop failure. It is a challenge for exploring novel antibacterial materials around the world because of its necessity and importance. In this study, a typical antibacterial metal complex, SalPhen zinc complex (SalPZn), was conjugated with another kind of antibacterial copolymer sweetsop-shape nanospheres (PSNs) by in-situ copolymerization in aqueous solution. The obtained PSNs conjugating SalPZn (SalPZn@PSNs) was constructed by double antibacterial centers. Its structure, composition and properties were characterized by Fourier-transform infrared spectra (FT-IR), scanning electron microscope (SEM), X-ray photoelectron spectroscopy (XPS), dynamic light scattering (DLS), and ICP Mass Spectrometer (ICP-MS). The antibacterial activity of SalPZn@PSNs was evaluated against the typical human pathogens Escherichia coli ( E. coli, gram-negative ), Staphylococcus aureus ( S. aureus, gram-positive ), and Valsa mali ( V. mali ), a typical apple saprophytic fungi. It indicated that SalPZn@PSNs not only presented an excellent antibacterial activity but also have the broad-spectrum antibacterial activity, and further expands its application range. The synergistic antibacterial mechanism was investigated. In summary, a novel antibacterial polymer material with double active centers was successfully synthesized and expected to be applied in agriculture and medicine.