Recent advances and applications of microspheres and nanoparticles in transarterial chemoembolization for hepatocellular carcinoma. (17th August 2021)

• Record Type: Journal Article
• Authors: Jia, Guorong; Van Valkenburgh, Juno; Chen, Austin Z.; Chen, Quan; Li, Jindian; Zuo, Changjing; Chen, Kai
• Is Part Of: Wiley interdisciplinary reviews. Volume 14:Number 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-08-17
• Subjects: hepatocellular carcinoma -- imaging -- microspheres -- nanoparticles -- therapy -- transarterial chemoembolization; Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; Biotechnology -- Periodicals; Ultrastructure (Biology) -- Periodicals; 610.28
• DOI: 10.1002/wnan.1749
• Languages: English
• ISSNs: 1939-5116

Abstract

Abstract: Transarterial chemoembolization (TACE) is a recommended treatment for patients suffering from intermediate and advanced hepatocellular carcinoma (HCC). As compared to the conventional TACE, drug‐eluting bead TACE demonstrates several advantages in terms of survival, treatment response, and adverse effects. The selection of embolic agents is critical to the success of TACE. Many studies have been performed on the modification of the structure, size, homogeneity, biocompatibility, and biodegradability of embolic agents. Continuing efforts are focused on efficient loading of versatile chemotherapeutics, controlled sizes for sufficient occlusion, real‐time detection intra‐ and post‐procedure, and multimodality imaging‐guided precise treatment. Here, we summarize recent advances and applications of microspheres and nanoparticles in TACE for HCC. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Abstract : Recent progress in the application of microspheres and nanoparticles for transarterial chemoembolization of hepatocellular carcinoma.