Bone remodeling following mandibular reconstruction using fibula free flap. (March 2022)

• Record Type: Journal Article
• Authors: Zheng, Keke; Yoda, Nobuhiro; Chen, Junning; Liao, Zhipeng; Zhong, Jingxiao; Wu, Chi; Wan, Boyang; Koyama, Shigeto; Sasaki, Keiichi; Peck, Christopher; Swain, Michael; Li, Qing
• Is Part Of: Journal of biomechanics. Volume 133(2022)
• Publication Date: 2022-03
• Subjects: Bone remodelling -- Maxillofacial reconstruction -- Placement design of fixation plate -- Time-dependent remodelling algorithm. Clinical follow-up; Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2022.110968
• Languages: English
• ISSNs: 0021-9290

Abstract

Abstract: To investigate bone remodelling responses to mandibulectomy, a joint external and internal remodelling algorithm is developed here by incorporating patient-specific longitudinal data. The primary aim of this study is to simulate bone remodelling activity in the conjunction region with a fibula free flap (FFF) reconstruction by correlating with a 28-month clinical follow-up. The secondary goal of this study is to compare the long-term outcomes of different designs of fixation plate with specific screw positioning. The results indicated that the overall bone density decreased over time, except for the Docking Site (namely DS1, a region of interest in mandibular symphysis with the conjunction of the bone union), in which the decrease of bone density ceased later and was followed by bone apposition. A negligible influence on bone remodeling outcome was found for different screw positioning. This study is believed to be the first of its kind for computationally simulating the bone turn-over process after FFF maxillofacial reconstruction by correlating with patient-specific follow-up.