A Convenient Esterification of N‐Heteroarene Methanols via C–CN Bond Cleavage of Benzoyl Cyanides as Acylating Sources. Issue 9 (4th March 2022)

• Record Type: Journal Article
• Authors: Su, Fangyao; Zhao, Qianrui; Wang, Mengzhuo; Zhao, Mingzhang; Ren, Yihe; Zhu, Binghan; Chen, Haoran; Lai, Miao; Zhao, Mingqin
• Is Part Of: ChemistrySelect. Volume 7:Issue 9(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-03-04
• Subjects: N-heteroarene methanols -- benzoyl cyanides -- esterification -- N-heteroarenemethyl esters -- simply mixing conditions; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202104272
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: An efficient and straightforward methodology for the esterification of various N ‐heteroarene methanols using benzoyl cyanides as acylating sources through a simply mixing conditions has been reported. The acyl groups were in‐situ generated via chemoselective C–CN bond cleavage to give the N ‐heteroarenemethyl esters. This process features in readily accessible starting materials and offers an easy operational procedure, and broad substrate scope with excellent selectivity. Abstract : The novel, practical and high efficiency reaction for acylation of N ‐heteroaryl methanols with benzoyl cyanides via C–CN bond cleavage is presented here. The protocol provides a direct approach to N ‐heteroarenemethyl esters through a simply mixing operation.