Copper‐Free Click Chemistry: Applications in Drug Delivery, Cell Tracking, and Tissue Engineering. Issue 10 (28th January 2022)

• Record Type: Journal Article
• Authors: Yoon, Hong Yeol; Lee, Donghyun; Lim, Dong‐Kwon; Koo, Heebeom; Kim, Kwangmeyung
• Is Part Of: Advanced materials. Volume 34:Issue 10(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-01-28
• Subjects: click chemistry -- drug delivery -- hydrogels -- imaging probe -- metabolic glycoengineering -- nanoparticles; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202107192
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract: Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or high pressure. However, copper‐free click chemistry has been shown to have favorable reaction rates and orthogonality in water, buffer solutions, and physiological conditions without toxic catalysts. Strain‐promoted azide‐alkyne cycloaddition and inverse electron‐demand Diels–Alder reactions are representative of copper‐free click chemistry. Artificial chemical reactions via click chemistry can also be used outside of the laboratory in a controllable manner on live cell surfaces, in the cytosol, and in living bodies. Consequently, copper‐free click chemistry has many features that are of interest in biomedical research, and various new materials and strategies for its use have been proposed. Herein, recent remarkable trials that have used copper‐free click chemistry are described, focusing on their applications in molecular imaging and therapy. The research is categorized as nanoparticles for drug delivery, imaging agents for cell tracking, and hydrogels for tissue engineering, which are rapidly advancing fields based on click chemistry. The content is based primarily on the experience with click chemistry‐based biomaterials over the last 10 years. Abstract : Copper‐free click chemistry is applicable outside of the laboratory, as it can be used controllably on cell surfaces, in the cytosol, and in living bodies. It is consequently of interest to biomedical researchers, and various new materials have been proposed. They can be categorized as nanoparticles for drug delivery, imaging agents for cell tracking, and hydrogels for tissue engineering.