Catalytic antimicrobial therapy using nanozymes. (22nd December 2021)

• Record Type: Journal Article
• Authors: Wang, Qian; Jiang, Jing; Gao, Lizeng
• Is Part Of: Wiley interdisciplinary reviews. Volume 14:Number 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-12-22
• Subjects: antibacterial -- antifungal -- antiviral -- catalytic therapy -- nanozymes; Nanomedicine -- Periodicals; Nanotechnology -- Periodicals; Biotechnology -- Periodicals; Ultrastructure (Biology) -- Periodicals; 610.28
• DOI: 10.1002/wnan.1769
• Languages: English
• ISSNs: 1939-5116

Abstract

Abstract: Nanozymes are nanomaterials with enzyme‐like characteristics, which catalyze the conversion of enzyme substrates and follow enzymatic kinetics under physiological conditions. As a new generation of artificial enzymes, nanozymes provide alternative approaches for those upon enzymatic catalysis. Compared with natural enzymes, nanozymes have the advantages of simple preparation, good stability and low cost, which makes nanozymes promising for application in many fields, such as antimicrobial infection treatment. Many studies have reported that nanozymes are capable of killing a number of pathogenic bacteria with resistance, fungi as well as viruses, and have shown great curative effects for diseases caused by these pathogens. Herein, we summarize the application of nanozymes for antibacterial, antiviral, and antifungal therapies and outline the issues needing resolution in the future. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Abstract : Nanozymes with intrinsic enzyme‐like activities provide alternative approaches for antibacterial, antiviral, and antifungal treatments, which is different from traditional antibiotic mechanisms and might help fight against drug resistance of microbial infections.