Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c. (4th March 2022)

• Record Type: Journal Article
• Authors: Shaha, Sumaiyah; Patel, Khushali; Saadat, Saba; Panahi, Sareh; de Almeida, Monique M.; Voronova, Anastassia; Riddell, Meghan
• Is Part Of: Placenta. Volume 119(2022)
• Page Start: 39
• Page End: 43
• Publication Date: 2022-03-04
• Subjects: Placenta -- Trophoblast -- Atypical protein kinase-c -- Trophoblast stem cells; aPKC atypical protein kinase-c; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2022.01.015
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Atypical protein kinase-c (aPKC) isoforms are important regulators of polarity and stem cell differentiation. There are three isoforms of aPKC: aPKC-ι, aPKC-ζ, and PKM-ζ. Recently, aPKC-ι was shown to regulate human trophoblast stem cell (TSC) differentiation. Compensation by remaining isoforms when a single aPKC isoform is lost can occur, but the expression pattern of aPKC-ζ in placenta is unknown. Here we show that aPKC-ι, aPKC-ζ and a new isoform, aPKC-ζ III, are expressed in trophoblasts. Therefore, studies examining the role of aPKC isoforms that control for potential compensation between aPKC isoforms are necessary to understand aPKC-mediated regulation of TSC differentiation. Highlights: Simultaneous expression of three isoforms of aPKC occur in trophoblasts. Trophoblasts express a novel isoform of aPKC- aPKC-ζ III. Further study is needed to understand isoform specific and redundant functions.