Early relapse detection by monitoring of circulating cell-free DNA in patients with localized head and neck squamous cell carcinoma: A subgroup analysis of the multicenter randomized clinical trial IMSTAR-HN. (March 2022)

• Record Type: Journal Article
• Authors: Jonas, Hanna; Simnica, Donjete; Bußmann, Lara; Zech, Henrike; Doescher, Johannes; Laban, Simon; Busch, Chia-Jung; Binder, Mascha
• Is Part Of: Oral oncology. Volume 126(2022)
• Publication Date: 2022-03
• Subjects: HNSCC -- Liquid biopsy -- ddPCR -- TP53; Mouth -- Cancer -- Periodicals; Mouth -- Tumors -- Periodicals; Mouth Diseases -- Periodicals; Mouth Neoplasms -- Periodicals; Bouche -- Cancer -- Périodiques; Bouche -- Tumeurs -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9943105
• DOI: 10.1016/j.oraloncology.2022.105733
• Languages: English
• ISSNs: 1368-8375

Abstract

Highlights: Liquid biopsy monitoring is feasible in head and neck cancer patients. Cell-free DNA mutations after surgery identify patients at risk for early relapse. Increasing variant allele frequencies precede clinical progression.