Carboline derivatives based on natural pityriacitrin as potential antifungal agents. (April 2022)

• Record Type: Journal Article
• Authors: Huang, Daye; Zhang, Zhigang; Li, Yanyan; Liu, Fang; Huang, Wenbo; Min, Yong; Wang, Kaimei; Yang, Jingzhong; Cao, Chunxia; Gong, Yan; Ke, Shaoyong
• Is Part Of: Phytochemistry letters. Volume 48(2022)
• Page Start: 100
• Page End: 105
• Publication Date: 2022-04
• Subjects: Carboline alkaloids -- Carboline derivatives -- Antifungal activity -- Broad-spectrum; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.02.010
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Carboline alkaloids are a class of important heterocyclic natural products, which usually present extensive bioactivities. During the course of our research for active compounds from natural products, the pityriacitrin and pityriacitrin B belonged carboline alkaloids have been isolated from a Chinese Burkholderia sp. NBF227, which indicated potential antifungal activities. So, in order to develop these carboline alkaloids as potential fungicidal agents, a series of pityriacitrin derivatives were investigated for their antifungal activities against Phytophthora capsici, Sclerotinia sclerotiorum, Botrytis cinerea and Rhizoctonia solani, and the results demonstrated that compounds 4, 10 and 19 displayed broad-spectrum antifungal activities. In addition, in vivo bioassay also indicated that compounds 4 and 10 could protect the pepper leaves and grape fruits against infection by P . capsici and B . cinerea, respectively. The possible mechanism of antifungal action for these compounds was also explored. Graphical Abstract: ga1 Highlights: Carboline derivatives displayed broad-spectrum in vitro fungicidal activities. Compounds 4 and 10 could protect the pepper leaves against infection by P. capsici. Compounds 4 could protect the grape fruits against infection by B. cinerea. The possible mechanism of antifungal action for compound 4 has also been explored.