Boron-catalyzed α-C–H fluorination of aryl acetic acids. Issue 5 (26th January 2022)

• Record Type: Journal Article
• Authors: Hu, Haipeng; Wang, Cuilin; Wu, Xin; Liu, Yangu; Yue, Guizhou; Su, Gehong; Feng, Juhua
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 5(2022)
• Page Start: 1315
• Page End: 1320
• Publication Date: 2022-01-26
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d1qo01814k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A catalytic α-fluorination reaction between the aryl acetic acid and selectfluor was established in the presence of a boron catalyst. A number of α-fluoro aryl acetic acids were generated in up to 96% yield, including several bioactive molecules. Abstract : The catalytic α-C–H fluorination of aryl acetic acids was achieved with good functional group tolerance in the presence of a boron catalyst. A series of α-fluoro aryl acetic acids were obtained in a single step with high yields (up to 96%). The catalytic reaction was employed for the synthesis of bioactive molecules and the modification of profen drugs. Moreover, the reaction could be performed on a gram scale. Further transformations were carried out.