Highly hydrophilic quaternary ammonium salt containing organotin (IV) carboxylate for visualization of antibacterial action and multi-photon absorption activity. (April 2022)

• Record Type: Journal Article
• Authors: Xu, Jing; Wang, Tao; Fang, Zhiyun; Cai, Xiancheng; Dai, Wenxuan; Wang, Jingmin; Tian, Xiaohe; Xu, Xinsheng; Zhang, Qiong; Tian, Yupeng
• Is Part Of: Dyes and pigments. Volume 200(2022)
• Publication Date: 2022-04
• Subjects: Bacteria imaging -- Multi-photon -- Organic tin -- Nucleic acid; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2022.110186
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: Antibiotics with multi-photon absorption are expected to play an important role in biomedicine. A novel mononuclear organotin complex RJSnBu3 is designed, synthesized and systematically studied in this work. It is found that RJSnBu3 has a suitable three-photon active cross section under 1400 nm excitation (NIR II region). RJSnBu3 can inhibit the growth of Galanz-positive bacteria (Bacillus subtilis) and Galanz-negative bacteria (Escherichia coli) in the antibacterial screening. Compared to kanamycin, RJSnBu3 has excellent inhibitory effect on Bacillus subtilis. Importantly, the results of in vitro nucleic acid titration and two-photon bacterial imaging shows that RJSnBu3 can damage the bacteria cell membrane. The cytosol flows out when RJSnBu3 binds to DNA, causing the bacteria to die. The multi-photon in vivo imaging results reveal that RJSnBu3 could be ultra-sensitive for detection of colitis mice. These results provide that RJSnBu3 has promising applications for multiphoton imaging and the development of specific antibacterial drugs. Graphical abstract: RJSnBu3 has a suitable three-photon active cross section under 1400 nm excitation (NIR II region). Compared to kanamycin, RJSnBu3 has excellent inhibitory effect on Bacillus subtilis. Importantly, the results of in vitro nucleic acid titration and two-photon bacterial imaging shows that RJSnBu3 can damage the bacteria cell membrane. The cytosol flows out when RJSnBu3 binds to DNA, causing the bacteria to die. The multi-photon in vivo imaging results reveal that RJSnBu3 could be ultra-sensitive for detection of colitis mice in vivo . Image 1 Highlights: RJSnBu3 has a three photon cross section 4.08 × 10 −81 cm 6 s 2 /mol −2 under 1400 nm excitation. RJSnBu3 has good antibacterial activity against B. Subtilis. RJSnBu3 showed obviously responded to antibacterial with "Off-On-Off" process through two-photon bacterial imaging. RJSnBu3 could be ultra-sensitive for detection of colitis mice by multi-photon in vivo imaging system.