Acrocalysterols A and B, two new steroids from endophytic fungus Acrocalymma sp. (April 2022)

• Record Type: Journal Article
• Authors: Yang, Ting; Liu, Jie; Lin, Li-Bin; Hu, Jia-Yao; Wu, Guang-Wei; Fan, Pei-Hong; Duan, Dong-Zhu; Xiao, Jian; Wang, Xiao-Ling
• Is Part Of: Phytochemistry letters. Volume 48(2022)
• Page Start: 77
• Page End: 80
• Publication Date: 2022-04
• Subjects: Sinomenium acutum -- Endophytic fungus -- Acrocalymma sp. -- Steroid -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2022.02.003
• Languages: English
• ISSNs: 1874-3900

Abstract

Abstract: Two new steroids, named acrocalysterols A (1) and B (2), together with five known compounds were isolated and characterized from an endophytic fungus Acrocalymma sp., isolated from the tender stems of Sinomenium acutum . The structures of the isolated metabolites were identified based on UV, IR NMR (1D and 2D), HR-ESI-TOF-MS, single-crystal X-ray diffraction experiment using Cu Kα radiation and CD spectra associated with TD-DFT calculation. The bioassay showed that compound 2 displayed potent cytotoxicity against three cancer cell lines HeLa, HCC-1806, and RKO with IC50 values ranging from 18.37 to 19.64 μM. Graphical Abstract: ga1 Highlights: Two new steroids were identified from an endophytic fungus Acrocalymma sp. The absolute configuration of compounds 1 and 2 were determined. 2 showed potent cytotoxicity against tumor cell lines HeLa, HCC-1806, and RKO.