Electrochemical oxidative N–H/P–H cross-coupling with H2 evolution towards the synthesis of tertiary phosphines. Issue 10 (22nd February 2022)

• Record Type: Journal Article
• Authors: Yuan, Yong; Liu, Xue; Hu, Jingcheng; Wang, Pengjie; Wang, Shengchun; Alhumade, Hesham; Lei, Aiwen
• Is Part Of: Chemical science. Volume 13:Issue 10(2022)
• Page Start: 3002
• Page End: 3008
• Publication Date: 2022-02-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/d1sc07248j
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A facile and novel electrochemical oxidative N–H/P–H cross-coupling method for obtaining tertiary phosphines(iii ) was developed. Abstract : Tertiary phosphines(iii ) find widespread use in many aspects of synthetic organic chemistry. Herein, we developed a facile and novel electrochemical oxidative N–H/P–H cross-coupling method, leading to a series of expected tertiary phosphines(iii ) under mild conditions with excellent yields. It is worth noting that this electrochemical protocol features very good reaction selectivity, where only a 1 : 1 ratio of amine and phosphine was required in the reaction. Moreover, this electrochemical protocol proved to be practical and scalable. Mechanistic insights suggested that the P radical was involved in this reaction.