NHC–palladium-catalyzed ionic liquid-accelerated regioselective oxyarylation of alkynes with diaryl ethers. Issue 5 (21st February 2022)

• Record Type: Journal Article
• Authors: Li, Jianxiao; He, Dan; Lin, Zidong; Cen, Liying; Wu, Wanqing; Jiang, Huanfeng
• Is Part Of: Green chemistry. Volume 24:Issue 5(2022)
• Page Start: 1983
• Page End: 1988
• Publication Date: 2022-02-21
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc04556c
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A palladium-catalyzed regioselective oxyarylation of oxime ether with diaryl ethers in a task-specific ionic liquid as an environmentally benign medium was accomplished. Abstract : The first NHC–palladium-catalyzed regioselective oxyarylation of oxime ether in a task-specific ionic liquid via C(sp 3 )–O and C(sp 2 )–O bond cleavage of two different types of ethers for the assembly of structurally diverse 4-arylisoxazoles is described. Both the basic ionic liquid [C3 NH2 mim]Br and NHC–Pd catalyst IPr–Pd–Im–Cl2 played an important role in this transformation. Notably, this new approach provides a practical and straightforward route to access a broad range of privileged 4-arylisoxazole structures with good yields and excellent regioselectivities. Significantly, this catalytic system can be recycled up to eight times without significant loss of catalytic activity.