An aerobic copper-mediated domino process for the synthesis of 3-(trifluoromethylseleno)indoles. Issue 10 (25th February 2022)

• Record Type: Journal Article
• Authors: Wang, Hui; Yao, Yunfei; You, Yi; Huang, Yangjie; Weng, Zhiqiang
• Is Part Of: Organic & biomolecular chemistry. Volume 20:Issue 10(2022)
• Page Start: 2115
• Page End: 2120
• Publication Date: 2022-02-25
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/d2ob00063f
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An aerobic copper-mediated domino reaction for the synthesis of 3-(trifluoromethylseleno)indoles by trifluoromethylselenolation of N -Ts 2-alkynylaniline with [(bpy)CuSeCF3 ]2 is described. Abstract : An aerobic copper-mediated domino reaction for the synthesis of 3-(trifluoromethylseleno)indoles by trifluoromethylselenolation of N -Ts 2-alkynylaniline with [(bpy)CuSeCF3 ]2 is reported. This reaction proceeds through sequential oxidation, alkyne coordination, and deprotonation followed by reductive elimination. This mild and robust method is highly functional group tolerant and provides straightforward access to 3-(trifluoromethylseleno)indoles in moderate to good yields.