Spatiotemporal regulation of store-operated calcium entry in cancer metastasis. (17th December 2021)

• Record Type: Journal Article
• Authors: Lu, Fujian; Li, Yunzhan; Lin, Shengchen; Cheng, Heping; Yang, Shengyu
• Is Part Of: Biochemical Society transactions. Volume 49:Number 6(2021)
• Page Start: 2581
• Page End: 2589
• Publication Date: 2021-12-17
• Subjects: calcium imaging -- cell invasion -- metastasis -- store-operated channels; Biochemistry -- Congresses; 572
• DOI: 10.1042/BST20210307
• Languages: English
• ISSNs: 0300-5127

Abstract

Abstract : The store-operated calcium (Ca 2+ ) entry (SOCE) is the Ca 2+ entry mechanism used by cells to replenish depleted Ca 2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics. There is recent evidence supporting that SOCE is critical for the spatial and the temporal coding of Ca 2+ signals in the cell. In this review, we critically examined the spatiotemporal control of SOCE signaling and its implication in the specificity and robustness of signaling events downstream of SOCE, with a focus on the spatiotemporal SOCE signaling during cancer cell migration, invasion and metastasis. We further discuss the limitation of our current understanding of SOCE in cancer metastasis and potential approaches to overcome such limitation.