A multi-environments-gene interaction study of anxiety, depression and self-harm in the UK Biobank cohort. (March 2022)

• Record Type: Journal Article
• Authors: Li, Chun'e; Liang, Xiao; Cheng, Shiqiang; Wen, Yan; Pan, Chuyu; Zhang, Huijie; Chen, Yujing; Zhang, Jingxi; Zhang, Zhen; Yang, Xuena; Meng, Peilin; Zhang, Feng
• Is Part Of: Journal of psychiatric research. Volume 147(2022)
• Page Start: 59
• Page End: 66
• Publication Date: 2022-03
• Subjects: Depression -- Anxiety -- Self-harm -- Multi-environments-gene interaction; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2022.01.009
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: The effects of gene-by-environment (G×E) interactions on complex diseases are significant, especially the superimposed effects of multiple environmental factors. However, research on the multi-environments-gene interactions of anxiety, depression, and self-harm is still limited. This study included white individuals (N = 66, 041–74, 482) from the UK Biobank. We fitted all environmental factors to a single environmental score (ES), and the estimated ES was used to calculate the multiplicative interaction effects between ES and genome-wide SNPs. Heritability was stratified by minor allele frequency (MAF) and linkage disequilibrium (LD). Our research found 10 loci with significant interaction effects, such as rs114830993 (PRICKLE2, P = 2.30 × 10 −8 ), rs151323364 (ASTN2, P = 2.71 × 10 −10 ) and rs536631793 (SYN3, P = 4.09 × 10 −8 ). In addition, we found that G×E heritability has a significant contribution to the depression of Patient Health Questionnaire-9 (PHQ-9) scores (h 2 G×E (female) = 6.1%, h 2 G×E (male) = 8.7%). Our research supported the important influence of multi-environments-gene interactions on anxiety, depression, and self-harm and provided clues for the prevention and etiological research of them.