Ru-Catalyzed C–H alkenylation on the arene ring of pirfenidone using pyridone as a directing group. Issue 21 (22nd February 2022)

• Record Type: Journal Article
• Authors: Raziullah, ; Kumar, Mohit; Ahmad, Ashfaq; Dutta, Himangsu Sekhar; Rastogi, Anushka; Gangwar, Manoj Kumar; Koley, Dipankar
• Is Part Of: Chemical communications. Volume 58:Issue 21(2022)
• Page Start: 3481
• Page End: 3484
• Publication Date: 2022-02-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/d2cc00257d
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A method to functionalize the arene ring of pirfenidone has been demonstrated using pyridone as a directing group. Abstract : A method to functionalize the arene ring of pirfenidone has been demonstrated using pyridone as a directing group. Unlike the functionalization of the pyridone nucleus, the method demonstrated here is the alkenylation of the N -aryl ring of pirfenidone with internal alkynes using ruthenium catalyst. High functional group tolerance, simple reaction conditions and site-selective functionalization permit the synthesis of new analogues of drugs in a step-economical manner. The data of the control experiments suggest the possibilities of a base-assisted internal electrophilic substitution (BIES) pathway.