Preoperative Helical Dynamic Enhanced Multidetector Row Computed Tomography: Can It Be a Prognostic Indicator in Early-Stage Non–small Cell Lung Cancer?. Issue 2 (March 2022)

• Record Type: Journal Article
• Authors: Moon, Jung Won; Yi, Chin A; Lee, Kyung Soo; Woo, Sook Young; Kwon, O Jung; Yang, Ehwa; Kim, Jae-Hun; Han, Joungho
• Is Part Of: Journal of computer assisted tomography. Volume 46:Issue 2(2022)
• Page Start: 308
• Page End: 314
• Publication Date: 2022-03
• Subjects: NSCLC -- DCE CT -- peak enhancement -- net enhancement -- overall or progression-free or metastasis-free survival; Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000001270
• Languages: English
• ISSNs: 0363-8715

Abstract

Abstract : Objective: This study aimed to investigate the prognostic significance of dynamic contrast-enhanced computed tomography in patients with stage IA non–small cell lung cancer (NSCLC). Methods: We retrospectively enrolled 139 patients (77 men, 62 women; mean age, 59 years) with stage IA NSCLC who underwent dynamic contrast-enhanced computed tomography. Data on age, pathologic subtype, peak enhancement, and net enhancement of primary lung cancer were collected and correlated with 5-year survival. Results: Peak enhancement had a significant correlation with overall survival in the univariable analysis (hazard ratio [HR], 1.18, confidence interval [CI], 1.01–1.38; P = 0.04) and in the multivariable analysis (HR, 1.19; CI, 1.01–1.39; P = 0.04). Patients with peak enhancement of 90 Hounsfield unit or higher had a significantly increased risk of death compared with patients with less enhancement after curative surgery (HR, 4.15; CI, 1.23–13.95; P = 0.02). Conclusions: Our study confirmed the prognostic significance of peak enhancement as an indicator for the overall survival of stage IA NSCLC.