Skin Cancer Back to Basics: Anogenital Squamous Cell Carcinoma. Issue 2 (March 2022)

• Record Type: Journal Article
• Authors: Dhillon, Soneet; Lake, Eden
• Is Part Of: Journal of the Dermatology Nurses' Association. Volume 14:Issue 2(2022)
• Page Start: 76
• Page End: 81
• Publication Date: 2022-03
• Subjects: Anogenital Squamous Cell Carcinoma -- Condyloma Acuminata -- Genital Warts -- HPV Vaccine -- Human Papilloma Virus (HPV) -- Squamous Intraepithelial Neoplasia; Dermatologic nursing -- Periodicals; Skin Diseases -- nursing -- Periodicals; Dermatology -- Periodicals; Dermatologic nursing; Periodicals; 616.505
• DOI: 10.1097/JDN.0000000000000671
• Languages: English
• ISSNs: 1945-760X

Abstract

ABSTRACT: Anogenital squamous cell carcinoma is rare but an often-invasive malignancy that is becoming an increasingly prevalent public health problem. Infection with high-risk human papillomavirus variants plays a critical role in disease progression and occurrence. Immunosuppressive treatment, positive HIV status, number of sexual partners, and history of smoking increase neoplastic progression. Early diagnosis and treatment are pivotal in managing anogenital malignancies to improve quality of life and minimize extensive surgical excision. This article reviews lesion categorization, epidemiology, human-papillomavirus-driven dysplastic epithelial changes, risk factors, diagnostic criteria, treatment options, and prophylactic measures to improve patient outcomes.