Cutaneous Plasmacytosis and Idiopathic Multicentric Castleman Disease: A Spectrum of Disease?. (28th April 2022)

• Record Type: Journal Article
• Authors: Drissi, Madeeha; Dunlap, Rachel; Clayton, Lara; Raess, Philipp W.; Mengden Koon, Stephanie; White, Kevin
• Is Part Of: American journal of dermatopathology. Volume 44:Number 4(2022)
• Page Start: 294
• Page End: 296
• Publication Date: 2022-04-28
• Subjects: cutaneous plasmacytosis, systemic plasmacytosis, idiopathic multicentric Castleman's disease, multicentric plasmacytic castleman's disease, multicentric Castleman's Disease, HHV-8; Skin -- Diseases -- Periodicals; Histology, Pathological -- Periodicals; 616.50705
• DOI: 10.1097/DAD.0000000000002109
• Languages: English
• ISSNs: 0193-1091

Abstract

Abstract: Cutaneous/systemic plasmacytosis (C/SP) is a plasma cell disorder characterized by reddish–brown patches, lymphadenopathy, and hypergammaglobulinemia. The degree to which C/SP overlaps with other plasma cell proliferative disorders and neoplasms is incompletely understood. We present the case of a patient with a several-year history of cutaneous plasmacytosis and evidence of systemic involvement with concurrent idiopathic multicentric Castleman disease (iMCD) involving a lymph node. There have been only a few reports of systemic iMCD preceded by a long, asymptomatic phase of cutaneous manifestations. We discuss the relationship between C/SP and iMCD and elaborate on the pathophysiological overlap of these 2 conditions and potential similarities in their pathogenesis. We suggest that the 2 diseases may represent the same entity presenting on a spectrum, with individuals diagnosed with C/SP at risk for progression to iMCD.