A tri-component semiconducting polymer with ultrahigh photothermal conversion efficiency as a biodegradable photosensitizer for phototheranostics. (24th November 2021)

• Record Type: Journal Article
• Authors: Gu, Yulan; Zhou, Guoqiang; Zhong, Yujie; Tan, Litao; Zheng, Zuhui; Qiu, Zihan; Wei, Bo; Shen, Lei; Yang, Jie; Zou, Dengfeng
• Is Part Of: Materials chemistry frontiers. Volume 6:Number 1(2022)
• Page Start: 8
• Page End: 14
• Publication Date: 2021-11-24
• Subjects: Materials science -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1039/d1qm01236c
• Languages: English
• ISSNs: 2052-1529

Abstract

Abstract : Semiconducting polymers usually with high photostability, reactive oxygen species (ROS) generation ability and photothermal conversion efficiency hold tremendous promise for phototherapy. Abstract : Semiconducting polymers usually with high photostability, reactive oxygen species (ROS) generation ability and photothermal conversion efficiency hold tremendous promise for phototherapy. In this study, a biodegradable tri-component semiconducting polymer (NDT) has been designed and synthesized for phototheranostics. NDT nanoparticles (NPs) obtained by nano-precipitation with an ultrahigh photothermal conversion efficiency (65.6%) could be degraded in the presence of hydrogen peroxide in the tumor microenvironment (TME). Such NPs show high phototoxicity towards human cervical cancer cells (HeLa) with laser irradiation as well as negligible dark toxicity. Furthermore, the in vivo study demonstrates that tumor growth was inhibited efficiently when mice were injected with NDT NPs, even with low power laser irradiation (0.2 W cm −2 ). In contrast, higher power density (0.5 W cm −2 ) led to complete tumor suppression. No side effects were observed towards normal tissues, which was confirmed by the H&E stained pictures of the normal tissues, including heart, liver, spleen, lung and kidney. Further, hematological, liver and renal function parameters indicate the biosafety of NDT NPs.