Electrophysiological signatures of brain aging in autism spectrum disorder. (March 2022)

• Record Type: Journal Article
• Authors: Dickinson, Abigail; Jeste, Shafali; Milne, Elizabeth
• Is Part Of: Cortex. Volume 148(2022)
• Page Start: 139
• Page End: 151
• Publication Date: 2022-03
• Subjects: Electrophysiology -- Autism spectrum disorder -- Aging -- Adults -- PAF -- Oscillatory slowing; Neuropsychology -- Periodicals; Nervous system -- Periodicals; Neurology -- Periodicals; Psychophysiology -- Periodicals; Behavior -- Periodicals; Neurology -- Periodicals; 612.825
• DOI: 10.1016/j.cortex.2021.09.022
• Languages: English
• ISSNs: 0010-9452

Abstract

Abstract: Recent evidence suggests that structural and functional brain aging is atypical in adults with autism spectrum disorder (ASD). However, it remains unclear if oscillatory slowing, a key marker of neurophysiological aging, follows an atypical trajectory in this population. This study examines patterns of age-related oscillatory slowing in adults with ASD, captured by reductions in the brain's peak alpha frequency (PAF). Resting-state electroencephalography (EEG) data from adults (18–70 years) with ASD ( N = 93) and non-ASD controls ( N = 87) were pooled from three independent datasets. A robust curve-fitting procedure quantified the peak frequency of alpha oscillations (7–13 Hz) across all brain regions. Associations between PAF and age were assessed and compared between groups. Consistent with characteristic patterns of oscillatory slowing, PAF was negatively associated with age across the entire sample ( p < .0001). A significant group-by-age interaction revealed that this relationship was more pronounced in adults with ASD ( p < .01). These findings invite further longitudinal investigations of PAF in adults with ASD to confirm if age-related oscillatory slowing is accelerated.