Heterobifunctional molecules tackle targeted protein dephosphorylation. (April 2022)

• Record Type: Journal Article
• Authors: Sibley, Christopher D.; Schneekloth, John S.
• Is Part Of: Trends in pharmacological sciences. Volume 43:Number 4(2022)
• Page Start: 263
• Page End: 265
• Publication Date: 2022-04
• Subjects: dephosphorylation -- PhosTACs -- heterobifunctional -- phosphatase -- phosphoprotein; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2022.01.005
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Recently, Chen and colleagues reported the development of phosphatase-targeting chimeric molecules (PhosTACs), heterobifunctional small molecules that promote targeted, proximity-induced protein dephosphorylation. This strategy represents an innovative approach to selectively manipulate phosphoprotein function and provides proof-of-concept for a new class of bifunctional small molecules in the chemical biologist's toolbox.