Sex under pressure: stress facilitates Leishmania in vitro hybridization. Issue 4 (April 2022)

• Record Type: Journal Article
• Authors: Monte-Neto, Rubens L.; Fernandez-Prada, Christopher; Moretti, Nilmar S.
• Is Part Of: Trends in parasitology. Volume 38:Issue 4(2022)
• Page Start: 274
• Page End: 276
• Publication Date: 2022-04
• Subjects: Leishmania -- genetic exchange -- hybrids -- sexual reproduction -- in vitro -- stress; Parasitology -- Periodicals; Parasitology -- Periodicals; Biology -- Periodicals; Parasitology; Biology; Parasitologie -- Périodiques; Online resources; 571.999
• DOI: 10.1016/j.pt.2022.02.001
• Languages: English
• ISSNs: 1471-4922

Abstract

Abstract : The selection of Leishmania hybrids in axenic culture was considered rare until recently, when Louradour and Ferreira et al ., demonstrated that induced DNA damage facilitates genetic exchange, resulting in full genome tetraploid progenies in vitro . Meiosis-related gene homologues HAP2, GEX1, and RAD51 were found to be involved, opening new avenues for functional genomic studies.