Evaluation of image-guided and surface-guided radiotherapy for breast cancer patients treated in deep inspiration breath-hold: A single institution experience. (March 2022)

• Record Type: Journal Article
• Authors: Penninkhof, Joan; Fremeijer, Kimm; Offereins-van Harten, Kirsten; van Wanrooij, Cynthia; Quint, Sandra; Kunnen, Britt; Hoffmans-Holtzer, Nienke; Swaak, Annemarie; Baaijens, Margreet; Dirkx, Maarten
• Is Part Of: Technical innovations & patient support in radiation oncology. Volume 21(2022)
• Page Start: 51
• Page End: 57
• Publication Date: 2022-03
• Subjects: Breath-hold -- Surface-guided radiotherapy -- DIBH -- Breast; DIBH Deep inspiratory breath-hold -- SGRT surface-guided radiotherapy -- DRRs digitally reconstructed radiographs -- CT computer tomography -- CBCT cone-beam CT -- OTM online treatment monitor -- (U V), ventral-dorsal and cranial-caudal direction in the tangential beam, respectively -- NAL no-action-level setup correction protocol -- eNAL extended NAL setup correction protocol -- VRT anterior-posterior direction -- LNG cranial-caudal direction -- LAT medio-lateral direction; Radiotherapy -- Periodicals; Cancer -- Radiotherapy -- Periodicals; Cancer -- Patients -- Hospital care -- Periodicals; 615.842
• DOI: 10.1016/j.tipsro.2022.02.001
• Languages: English
• ISSNs: 2405-6324

Abstract

Highlights: SGRT provides continuous non-invasive monitoring of patient's positioning and DIBH. Variation in positioning and DIBH requires daily online setup corrections. Setup using SGRT is slightly faster than laser-based setup, with similar accuracy. Visual feedback to the patient enhances DIBH compliance and reproducibility. Abstract: Introduction: Nowadays, deep inspiratory breath-hold is a common technique to reduce heart dose in left-sided breast radiotherapy. This study evaluates the evolution of the breath-hold technique in our institute, from portal imaging during dose delivery to continuous monitoring with surface-guided radiotherapy (SGRT). Materials and methods: Setup data and portal imaging results were analyzed for 98 patients treated before 2014, and SGRT data for 228 patients treated between 2018 and 2020. For the pre-SGRT group, systematic and random setup errors were calculated for different correction protocols. Residual errors and reproducibility of breath-holds were evaluated for both groups. The benefit of using SGRT for initial positioning was evaluated for another cohort of 47 patients. Results: Online correction reduced the population mean error from 3.9 mm (no corrections) to 1.4 mm. Despite online setup correction, deviations greater than 3 mm were observed in about 10% and 20% of the treatment beams in ventral-dorsal and cranial-caudal directions, respectively. However, these percentages were much smaller than with offline protocols or no corrections. Mean absolute differences between breath-holds within a fraction were smaller in the SGRT-group (1.69 mm) than in the pre-SGRT-group (2.10 mm), and further improved with addition of visual feedback (1.30 mm). SGRT for positioning did not improve setup accuracy, but slightly reduced the time for imaging and setup correction, allowing completion within 3.5 min for 95% of fractions. Conclusion: For accurate radiotherapy breast treatments using deep inspiration breath-hold, daily imaging and correction is required. SGRT provides accurate information on patient positioning during treatment and improves patient compliance with visual feedback.