Functionalized chitosan/spherical nanocellulose-based hydrogel with superior antibacterial efficiency for wound healing. (15th May 2022)

• Record Type: Journal Article
• Authors: Patel, Dinesh K.; Ganguly, Keya; Hexiu, Jin; Dutta, Sayan Deb; Patil, Tejal V.; Lim, Ki-Taek
• Is Part Of: Carbohydrate polymers. Volume 284(2022)
• Publication Date: 2022-05-15
• Subjects: Carboxymethyl chitosan -- Nanocellulose -- Injectable hydrogel -- Adhesive -- Recoverable -- Biocompatibility -- Wound healing; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119202
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Cellulose nanomaterials have received significant interest due to their superior physicochemical properties and biocompatibility. The nanomaterials-based hydrogel patches are widely explored for skin regeneration. However, the injectability and adhesiveness of the hydrogels are crucial challenges for tissue engineering applications. To overcome these, we synthesized an injectable and adhesive hydrogel of spherical nanocellulose (s-NC) reinforced carboxymethyl chitosan for rapid skin regeneration. The s-NC exhibited improved cellular activity than cellulose nanocrystals. The hydrogels exhibited adhesive and injectability potentials and were molded in the desired configurations. An enhanced conductivity was observed in s-NC added hydrogels than the pure polymer hydrogel. The skin regeneration potential of the hydrogel scaffolds was also examined in the rats using the wound healing model. The composite scaffolds also showed improved antibacterial potential. Taken together, the developed hydrogels have the potential and can be explored as a promising biomaterial for enhanced skin regeneration applications. Graphical abstract: Unlabelled Image Highlights: Spherical nanocellulose (s-NC) added hydrogels exhibited ~85% recovery strength. Synthesized hydrogels exhibited injectable and adhesive properties. The s-NC exhibited enhanced cellular activity than cellulose nanocrystals (CNCs). Enhanced skin cells proliferation was observed in s-NC loaded hydrogel. Improved wound healing occurred in s-NC loaded scaffolds than polymer scaffold.