Synthesis, characterization, and biological evaluation of novel selenium-containing chitosan derivatives. (15th May 2022)

• Record Type: Journal Article
• Authors: Chen, Wanwen; Cheng, Hao; Chen, Lingyun; Zhan, Xiaobei; Xia, Wenshui
• Is Part Of: Carbohydrate polymers. Volume 284(2022)
• Publication Date: 2022-05-15
• Subjects: Selenium polysaccharides -- Selenodiacetic acid -- Chitosan -- Selenium content -- Antioxidant -- Anticancer; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119185
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Though great efforts have been made to develop selenium polysaccharides with unique properties using HNO3 -Na2 SeO3 methods, the Se content is still low due to the poor esterification efficiency of H2 SeO3 . Herein, selenodiacetic acid (SA) was introduced into chitosan (CS) to synthesize O -selenodiacetyl chitosan (OSAC) and chitosan-ammonium selenodiacetate (CASA) by covalent and non-covalent interaction, respectively. The obtained CS derivatives were characterized by UV–vis, FTIR, 1 H NMR, XPS, TGA, and XRD spectra, and the OSAC and CASA showed high Se content up to 15, 720 ± 475 and 26, 363 ± 698 μg/g. The OSAC and CASA demonstrated increased antioxidant activities compared to the CS in DPPH and ABTS free radical scavenging assays. Moreover, they exhibited a potent anticancer effect on HepG2 cells with the IC50 values of 0.918 and 1.459 μg/mL. Taken together, this study provides a promising strategy for the design of novel selenium polysaccharides with high Se content and greater biological activity.