Lifespan extension and anti-oxidant effects of carotenoid pigments in Caenorhabditis elegans. (February 2022)

• Record Type: Journal Article
• Authors: Lee, Sang-Ah; Lim, Won-Hee; Van Le, Ve; Ko, So-Ra; Kim, Bomin; Oh, Hee-Mock; Ahn, Chi-Yong
• Is Part Of: Bioresource technology reports. Volume 17(2022)
• Publication Date: 2022-02
• Subjects: Haematococcus lacustris -- Carotenoids -- Caenorhabditis elegans -- Lifespan -- Antioxidation; Biomass energy -- Periodicals; Biotransformation (Metabolism) -- Periodicals; Agricultural wastes -- Periodicals; Factory and trade waste -- Periodicals; Organic wastes -- Periodicals; Waste products as fuel -- Periodicals; Waste products as fuel; Organic wastes; Factory and trade waste; Biotransformation (Metabolism); Biomass energy; Agricultural wastes; Periodicals; Electronic journals; 662.88
• DOI: 10.1016/j.biteb.2022.100962
• Languages: English
• ISSNs: 2589-014X

Abstract

Abstract: Haematococcus lacustris is a green unicellular alga known for its diverse beneficial carotenoids, such as β-carotene, canthaxanthin, and astaxanthin, with varying compositions at different morphological stages. Each carotenoid might affect the lifespan of Caenorhabditis elegans by inhibiting reactive oxygen species (ROS). C. elegans were fed with carotenoids either using the Escherichia coli OP50 that had pre-consumed commercial carotenoids and the optimal Haematococcus medium containing a dissolved carotenoid. As a result, lifespan of C. elegans was extended by 1.3 times. Three carotenoids indirectly protected C. elegans against ROS by upregulating the expression of superoxide dismutase (maximum 9.8 times) and catalase (maximum 2.5 times). Carotenoids reduced the concentration of malondialdehyde, a product of lipid peroxidation induced by ROS, by 11.2 times in C. elegans . These results suggest that carotenoids could induce antioxidation effect and prolong the lifespan of C. elegans . And H. lacustris could be the most versatile producer of carotenoids. Graphical abstract: Unlabelled Image Highlights: H. lacustris can be a versatile carotenoid producer depending on cultivation stages. SOD and CAT activities increased but MDA decreased in carotenoid-treated group. A higher anti-aging effect was achieved at a smaller dose than other studies. Lifespan of C. elegans was extended up to 1.3 times by carotenoid treatment.