Fungal exopolysaccharides: Properties, sources, modifications, and biomedical applications. (15th May 2022)

• Record Type: Journal Article
• Authors: Hamidi, Masoud; Okoro, Oseweuba Valentine; Milan, Peiman Brouki; Khalili, Mohammad Reza; Samadian, Hadi; Nie, Lei; Shavandi, Amin
• Is Part Of: Carbohydrate polymers. Volume 284(2022)
• Publication Date: 2022-05-15
• Subjects: aECM acellular extracellular matrix -- anti-TB anti-tuberculosis -- AuNPs gold nanoparticles -- BC bacterial cellulose -- βG β-glucan -- BRMs biological response modifiers -- CM-Scl carboxymethyl scleroglucan -- CHP cholesterol-modified pullulan -- CGC chitin–glucan complex -- ChGC chitosan–glucan complex -- CSPN chitosan-pullulan-silver-nanocomposite -- CR3 complement receptor 3 -- DB degree of branching -- DCs dendritic cells -- DEX-MA dextran methacrylate -- D-Glcp d-glucopyranose -- DFUs diabetic foot ulcers -- DBAP-PO dibutylaminopropyl carbamate pullulan octanoate -- DEAE diethyl amino ethyl -- DDSs drug delivery systems -- EPSs exopolysaccharides -- GPC gel permeation chromatography -- GPs glucan particles, Human Hepatocellular Carcinoma -- HPCys-Pul hydroxypropyl cyclosophoraose-pullulan -- IEC ion exchange chromatography -- IPN interpenetrating polymeric network -- LacCer lactosylceramide -- LAS Lasiodiplodan -- MWs molecular weights -- MGB myoglobin -- NPs nanoparticles -- OXPL oxidized pullulan -- PABA-QP para-aminobenzoic acid-quat188-pullulan -- PAMP pathogen-associated molecular pattern -- PRRs pattern recognition receptors -- PDGF platelet-derived growth factor -- PDA polydopamine -- PEI polyethyleneimine -- PSs polysaccharides -- PVA polyvinyl alcohol -- PUL pullulan -- PHG pullulan hydrogel -- PUL-MNs pullulan microneedle -- SC sacchachitin -- SCNF sacchachitin nanofibers -- SPG schizophyllan -- Scl scleroglucan -- Smf submerged fermentation -- STMP sodium trimetaphosphate -- SBG soluble β-Glucan -- TEMPO 2, 2, 6, 6-Tetramethylpiperidyl-1-Oxyl -- TE tissue engineering -- TF monocyte tissue factor -- TGF-β transforming growth factor beta -- VEGF vascular endothelial growth factor -- VitB12 vitamin B12; Chitosan (PubChem CID: 71853) -- Lentinan (PubChem CID: 37723) -- Pullulan (PubChem CID: 439586) -- Schizophyllan (PubChem CID: 24777) -- Scleroglucan (PubChem CID: 131750928); Exopolysaccharide -- Tissue engineering -- Drug delivery -- Gene delivery; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2022.119152
• Languages: English
• ISSNs: 0144-8617

Abstract

Abstract: Fungal exopolysaccharides (EPSs) are natural biopolymers with diverse potential applications in the biomedical, packaging, cosmetic, and food industries. Fungal EPSs are easy to extract and purify polysaccharides that are biodegradable, biocompatible, with low immunogenicity, bioadhesion ability, antibacterial activity, and contain different reactive groups such as hydroxyl, carboxyl, and amine for chemical modifications. Despite fast progress in identifying and characterization fungal EPSs for biomedical applications, i.e., wound healing, drug, and gene delivery, only a few products have been commercialized based on fungal EPSs. This review critically discusses potential biomedical applications of fungi sourced EPSs in tissue engineering (TE), drug and gene delivery. Graphical abstract: Unlabelled Image