Zoonotic spill-over of SARS-CoV-2: mink-adapted virus in humans. (March 2022)

• Record Type: Journal Article
• Authors: Rabalski, Lukasz; Kosinski, Maciej; Mazur-Panasiuk, Natalia; Szewczyk, Boguslaw; Bienkowska-Szewczyk, Krystyna; Kant, Ravi; Sironen, Tarja; Pyrc, Krzysztof; Grzybek, Maciej
• Is Part Of: Clinical microbiology and infection. Volume 28:Number 3(2022)
• Page Start: 451.e1
• Page End: 451.e4
• Publication Date: 2022-03
• Subjects: Mink -- SARS-CoV-2 -- Spill-over -- Transmission -- Zoonoses; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2021.12.001
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: Objectives: This work aimed to analyse possible zoonotic spill-over of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report the spill-over of mink-adapted SARS-CoV-2 from farmed mink to humans after adaptation that lasted at least 3 months. Methods: Next-generation sequencing and a bioinformatic approach were applied to analyse the data. Results: In an isolate obtained from an asymptomatic patient testing positive for SARS-CoV-2, we found four distinguishing mutations in the S gene that gave rise to the mink-adapted variant (G75V, M177T, Y453F, and C1247F) and others. Conclusions: Zoonotic spill-over of SARS-CoV-2 can occur from mink to human.