Microbial redox coenzyme engineering and applications in biosynthesis. Issue 4 (April 2022)

• Record Type: Journal Article
• Authors: Yang, Haiqian; Jia, Xiaojing; Han, Yejun
• Is Part Of: Trends in microbiology. Volume 30:Issue 4(2022)
• Page Start: 318
• Page End: 321
• Publication Date: 2022-04
• Subjects: oxidoreductase -- (reduced) nicotinamide adenine dinucleotide (phosphate) (NAD(P)+ and NAD(P)H) -- coenzyme regulation -- coenzyme regeneration -- biosynthesis; Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2022.01.012
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Many biosynthetic processes, either in vivo or in vitro, involve redox reactions catalyzed by oxidoreductases – which depend on coenzymes as electron carriers. Redox balance is regulated mainly by coenzymes NAD(P) + and NAD(P)H and is essential for biosynthesis. New techniques for the regulation and regeneration of coenzymes have recently advanced our understanding of, and demonstrated promising applications in, synthetic biology.