A case of synchronous triple autoimmune disorders secondary to thymoma: Pure red cell aplasia, Good's syndrome, and thymoma-associated multi-organ autoimmunity. (2022)

• Record Type: Journal Article
• Authors: Nakagawa, Yuta; Matsumoto, Kinnosuke; Yamamoto, Makoto; Hirata, Haruhiko; Shiroyama, Takayuki; Miyake, Kotaro; Yamamoto, Yuji; Kuge, Tomoki; Yoneda, Midori; Naito, Yujiro; Suga, Yasuhiko; Fukushima, Kiyoharu; Koyama, Shohei; Iwahori, Kota; Nagatomo, Izumi; Takeda, Yoshito; Kumanogoh, Atsushi
• Is Part Of: Respiratory medicine case reports. Volume 36(2022)
• Publication Date: 2022
• Subjects: Thymoma -- Pure red cell aplasia -- Good's syndrome -- Thymoma-associated multi-organ autoimmunity; Respiratory organs -- Diseases -- Periodicals; Chest -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Respiratory System -- Periodicals; Chest -- Diseases; Respiratory organs -- Diseases; Electronic journals; Periodicals; 616.2
• DOI: 10.1016/j.rmcr.2022.101619
• Languages: English
• ISSNs: 2213-0071

Abstract

Abstract: Pure red cell aplasia (PRCA), Good's syndrome (GS), and thymoma-associated multiorgan autoimmunity (TAMA) are associated with thymoma. Herein, we describe the case of a 56-year-old woman with PRCA, GS, and TAMA simultaneously. She was treated with cyclosporine, immunoglobulin supplementation, and prednisolone; however, she died of uncontrolled sepsis due to extreme immunosuppression. The combination of these three diseases is likely to lead to fatal infections, and to avoid such infections, it may be necessary to reduce or discontinue immunosuppressants and steroids as soon as possible if the diseases are controlled, as well as regular immunoglobulin supplementation.