A β-hairpin peptide with pH-controlled affinity for tumor cells. Issue 4 (7th December 2021)
- Record Type:
- Journal Article
- Title:
- A β-hairpin peptide with pH-controlled affinity for tumor cells. Issue 4 (7th December 2021)
- Main Title:
- A β-hairpin peptide with pH-controlled affinity for tumor cells
- Authors:
- Nishimura, Shin-nosuke
Nishida, Kei
Tanaka, Masaru - Abstract:
- Abstract : This peptide undergoes a pH-driven conformational switch between a random coil structure with a flexible linear RGD epitope and a β-hairpin structure with a rigid RGD loop. The β-hairpin-structured peptide is more readily internalized by tumor cells. Abstract : Considering that the pH in the tumor microenvironment is dysregulated, we designed a β-hairpin peptide (SSRFEWEFESS D PRGDPSSRFEWEFESS). The configuration of the peptide switched from a flexible linear to a rigid loop structure under weakly acidic conditions. The peptide internalized by tumor cells increased significantly under weakly acidic conditions.
- Is Part Of:
- Chemical communications. Volume 58:Issue 4(2022)
- Journal:
- Chemical communications
- Issue:
- Volume 58:Issue 4(2022)
- Issue Display:
- Volume 58, Issue 4 (2022)
- Year:
- 2022
- Volume:
- 58
- Issue:
- 4
- Issue Sort Value:
- 2022-0058-0004-0000
- Page Start:
- 505
- Page End:
- 508
- Publication Date:
- 2021-12-07
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/d1cc06218b ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 21023.xml